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Swisher SG , Jr P, JB, Feig BW, Miller MJ, Walsh GL

In this study, we generated a mouse model with phospho-ablation of the three canonical phosphorylation sites in RyR2 (S2031A/S2808A/S2814A, triple phospho-mutant (TPM)) to determine their role in the adrenergic response

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The structural zinc site is composed of four closely spaced cysteine ligands (Cys97, Cys100, Cys103, and Cys111 in the amino acid sequence) positioned in an almost symmetric tetrahedron around the Zn ion

Therefore, specific interventions targeting alcohol-induced Lys4 histone trimethylation or fibrosis gene expression could be employed as preventive measure against alcoholic liver fibrosis