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In this regard, it can be noted that transcription of the gdhA gene initiates from two promoters, one weak, constitutively expressed, called gdhA P1, and another, more potent, called gdhA P2, transactivated by GdhR, a transcriptional regulator whose DNA binding is inhibited by -ketoglutarate (Pagliarulo et al., 2004)

S2CID 245654240

according to medical genetics records, referral was not received for 33 of the 189

Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

It is interesting to observe that the protein levels of LXR and its target gene, ABCA1 , are downregulated in primary colon cancer specimens and in synchronous liver metastases (Lo Sasso et al., 2013)

Certain antidepressants such as Prozac might be used once to counter the psychological side effects of quitting duloxetine