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This is not systemic anti-inflammation distributed evenly across the body it is targeted suppression of the cells actively driving intestinal pathology

Lopes de Faria J, Silva K, Lopes de Faria J

Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome

In the atypical pathway, LPS activates caspase-4/5/11, which triggers cell membrane rupture and pyroptosis by cleaving GSDMD (Jin et al., 2023)

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However, much of the data supporting the contraindication and interaction is based on the use of intravenous methylene blue, or extrapolation of similar drugs that work on MAOIs