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You can read the abstract of this article at A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial The objective of this study was to evaluate the effects of lorcaserin on body weight, cardiovascular risk factors, and safety in obese and overweight patients

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The NIH Office of Dietary Supplements and the American Academy of Family Physicians identify the following groups as most vulnerable: Adults over 50 Age-related decline in stomach acid production reduces the ability to release B12 from food proteins