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Additional antioxidants like ascorbic acid (vitamin C) help release the NO that was bound to glutathione, recapturing the NO that the body has already produced.[52] This may be one mechanism by which antioxidants and natural substances like pomegranate and quercetinwhich provide high levels of polyphenols, which are natural antioxidantsalso have a positive effect on ED of a vascular etiology.[53],[54],[55] Antioxidants are also important for the formation of the NOS enzyme as well as maintaining it in its active, coupled state.[56],[57] When NOS becomes uncoupled, it reduces molecular oxygen to superoxide (a damaging free radical) instead of NO.[58] This may be one means by which the French Maritime pine bark [CD2] also has a positive impact on erectile function

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was a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (grant no

The authors findings were likely due to the small rises in NO observed in these studies, as they were not significantly different to the placebo (CM: 15.3 1.1

However, other snacks consumed throughout the day, such as chocolate, can also be sources of caffeine