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ALS pathogenic mutations identified in RNA-binding proteins (RBPs) include TAR DNA binding protein 43 (TDP-43), fused-in-sarcoma (FUS), Ewing sarcoma (EWS), TATA-binding protein-associated factor 15 (TAF15), and heterogeneous nuclear ribonucleoproteins (hnRNPs) 5,6

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Human activity includes smelting, refining and mining, this may results in lead concentration in the environment

10.1038/nrd1468 18 BabcockM.De SilvaD.OaksR.Davis-KaplanS.JiralerspongS.MonterminiL.et al (1997)

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