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In parallel, Cys and Gly, along with Gln and Asp, play important roles in suppressing oxidative stress, while Gln and Asp have been shown to positively influence the composition and function of the gut microbiota

whereas, ligand was prepared employing LigPrep 2.6 workflow in Schrdinger suite

While intended to prevent chemotherapy-induced neuropathy via SOD mimicry, the drug paradoxically exacerbated nerve damage in some cohorts [317, 318]

About this article Cite this article Xue, L., Gui, J., Pan, H

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Triptolide attenuates cancer cells by regulating the process of autophagy and ferroptosis Triptolide has been shown to exhibit antitumor effects in ovarian cancer (SK-OV-3 and SK-OV-3/DDP) cells by inducing autophagy through ROS generation and JAK2/STAT3 pathway inhibition, enhancing chemotherapy sensitivity and inhibiting tumor growth, as well as by inducing apoptosis and reducing the protein expression of MMP-2, Sorcin, and VEGF, thereby disrupting the Mcl-1/Beclin1 interaction and highlighting its multifaceted therapeutic potential [991, 992]