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Pycnogenol has been shown to exert anti-inflammatory and antithrombotic effects (26) by inhibiting Cox-1 and Cox-2 enzymatic activity (27), both involved in the inflammatory pathway

doi: 10.1056/NEJMoa1803917

Cells with less than 200 and greater than 6000 unique genes were also filtered

dataset showed that GPX4 demonstrated the highest variability (standard deviation of log2 fold changes = 0.39), followed by EIF3B (0.26) and ST3GAL1 (0.24)

It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation