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Importantly, degradation kinetics can be precisely controlled to match the therapeutic timelinefor instance, maintaining mechanical separation of organs during the full course of brachytherapy, while simultaneously providing sustained local delivery of radiosensitizers, chemotherapeutics, or immunomodulators [136]

Follow-up after trimodality therapy Following completion of TMT, patients require close surveillance to detect intravesical, upper-tract, urethral, nodal or distant recurrence, upper-tract or urethral disease, and treatment-related complications, as well as to identify candidates for timely salvage cystectomy

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