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Sample size calculation was based on previous studies investigating the effect of L-Carnitine on inflammatory markers [22], with TNF level differences as primary endpoint, and resulted in a recruitment goal of 90 patients (45 per treatment arm) for a statistical power of 90% with an error probability of 10% during the previous 6 month

Research in this field is rapidly developing, with many studies focusing on improving the stability and manufacturing methods associated with self-assembling peptide and protein vaccines [171]

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