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GH-Axis : Due to age-related decline in pituitary function, older adults may require a longer cycle duration (16-24 weeks) and may need to use the standard or advanced doses of GHSs to achieve a therapeutic effect

SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105

Pissios P, Bradley RL, Maratos-Flier E

G., Quadir, M

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