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ROS can directly attack DNA, causing oxidative damage (Taniguchi et al., 2012), including base damage and single-strand breaks, which can cause DNA to mutate and change structurally (Roy, 2014)

doi: 10.1111/j.1521-0391.2013.12034.x

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In some people, particularly older adults or those with limited protein intake, both glycine and cysteine availability may constrain glutathione synthesis

FI at m/z 142.1226 formed due to an alpha cleavage of the parent compound between the -carbon and the carbonyl group

Thus, we reasoned that Gclc expression and GSH are needed upon activation of FoB