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Interestingly, individual tumour-bearing mice exhibited an increase in circulating formate with disease progression while healthy mice did not show such an increase over time

437,438,439 While primarily acting as a tumor suppressor, cellular senescence also plays a critical role in tissue repair, promoting localized fibrosis and immune cell recruitment to clear damaged and senescent cells

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Hafez Hafez M, et al

Aukerman MM, Aukerman D, Bayard M, Tudiver F, Thorp L, Bailey B Exercise and restless legs syndrome: a randomized controlled trial