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Finally, through multicenter, large-sample clinical cohort studies combined with statistical methods, derive and validate clinically meaningful cutoff values to enable precise patient stratification and individualized treatment

While a clinical study found that a single 25 mg or 50 mg dose of goitrin inhibited thyroid radioiodine uptake, two 10 mg doses did not have this effect (146, 147)

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This unique action of increased 16-a-OHE1 in the presence of inflammation, followed by increase cell proliferation, makes 16-a-OHE1 advantageous in the absence of free-radicals and un-repaired DNA damage