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Appropriate dosage adjustments should be made for patients with impaired kidney function and duration of use should be as short as possible to minimize risks of undesired reactions [see Dosage and Administration (2.2)]

CTLA-4 inhibitor-associated granulomatous hepatitis is characterized by extensive lobular injury, including sinusoidal histiocytic proliferation and inflammatory endothelialitis of the central vein

Elevated GPVI levels have been linked to cardiovascular events such as acute coronary syndrome, myocardial infarction, ischemic stroke, and transient ischemic episodes

Results : Of 1,410 patients with idiosyncratic DILI, 64 cases had positive rechallenge (4.5%)

PMID: 25561511