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The decided inclusion criteria was: published case reports and series describing IGS patients, studies reporting patients of any age, sex or ethnicity with either genetically confirmed diagnosis or clinical diagnosis with documentation of vitamin B12 malabsorption and proteinuria, studies reporting explicit details on the dosage, frequency and route of administration of B12

In earlier studies, methods such as UVvisible spectrophotometry, neutron activation analyses, and graphite furnace atomic absorption spectrometry were commonly used

Most patients notice meaningful change after two months, which corresponds to approximately two full treatment cycles

10.3390/pr8040458 50 ConlonM.PoltorackC

Potential causes of treatment failure were evaluated in 4 patients, 2 of whom were overweight, 1 presenting with a L4L5 grade I spondylolisthesis and facet joint arthritis, and another with depressive symptoms