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In the ATP-binding pocket, the intermediate state had a conformation similar to that of the apo state, despite the drastic movement of the M-HEAT domain upon RHEB binding (Fig

Elevated glucose levels impair RPEC viability and function, accelerating DR progression

Effect of acute cold exposure on the expression of the adiponectin, resistin and leptin genes in rat white and brown adipose tissues

Ischemic cascade Immediately after the reduction in blood flow, oxygen and glucose levels decrease, further reducing adenosine triphosphate and energy-dependent processes [33]

Nat Cell Biol 12, 973981 (2010)

Recent studies demonstrated that the GHK tripeptide up and downregulates a large number of human genes, which may contribute to the health promoting effects of its copper complex