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Despite progress in neural repair research 3 , effective axonal regeneration and remyelination remain difficult to achieve, representing a major barrier to functional recovery

Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum

Activation of autophagy by CP contributes to its chemoresistance in esophageal cancer (ODonovan et al., 2011), ovarian cancer (Lin et al., 2017), and osteosarcoma (Jiang et al., 2017)

We used age-matched male mice in all animal experiments to avoid possible shielding of estrogen on heart failure

For instance, cystamine, a known PDI inhibitor [38], exerts a strong protection against BSO-induced ferroptosis, along with abrogation of BSO-induced accumulation of cellular NO, ROS and lipid peroxides

The Neh6 domain, which is a serine-rich region, contributes to regulate NRF2 stability and mediates the interaction with a third negative regulator, -transducin repeat-containing protein (-TrCP), through its DSGIS (Aspartic acid-Serine-Glycine-Isoleucine-Serine) and DSAPGS (Aspartic acid-Serine-Alanine-Proline-Glycine-Serine) motifs not recognized by KEAP1