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Thus, removal of the C-terminal L585 reduces the ability of the albumin fusions to engage human FcRn, and thereby compromises their rescue from intracellular lysosomal degradation

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The dashed line indicates the target concentration (TC) of the drug in the blood

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Casgevy, developed by Vertex Pharmaceuticals and CRISPR Therapeutics, has been hailed as curative for sickle cell disease (SCD) patients

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