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This effect is supported by increased glucose flux through the noncanonical PPP, resulting in higher NADPH production, which promotes lysosomal maturation and maintains intracellular redox balance, thereby facilitating more efficient clearance of ACs [92] (Fig

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Archived from the original on 27 March 2019

Animals All animal experiments were conducted in accordance with the ethical guidelines and approved by the Kyoto University Animal Research Committee (Approval No