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When Ure2p aggregates are formed in vivo , their stability is enhanced and they no longer bind properly the transcription factors, leading subsequently to the expression of genes used for poor nitrogen sources and a slow growth (Shewmaker et al., 2007)

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The efficacy of a single anti-angiogenesis targeted agent on the inhibition of tumor growth is short-lived 9

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Absorbance values were read in the spectrophotometer at 532 nm

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