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In contrast, early studies suggested that activated T cells adopt a glycolysis-centric phenotype, with a subsequent return to oxidative metabolism and FAO in memory T cells ( in vivo do not cycle carbons from glucose into lactate but rather transition these glucose carbons into intermediates of the TCA cycle (122)

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Altogether these findings completed an ancient negative feedback loop between AMPK and mTORC1 to coordinate nutrient-sensing with cell growth and division (Figure 3)

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