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Current clinical advancement strategies include structural engineering of vitamin K analogs (e.g., C11-alkyl chain-modified MK4-C11) to enhance brain bioavailability and adeno-associated virus (AAV)-mediated FSP1 gene delivery (NCT05543659) to restore vitamin K reduction capacity, driving the transformation of vitamin K from a fundamental nutrient into a clinically viable targeted ferroptosis therapeutic

doi: 10.1016/s0140-6736(24)02322-5 5 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

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The transcription factors hypoxia-inducible factor 1 and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis

L., Chan, N

Several neurodegenerative diseases are affected by disrupted mitochondrial activity, transport proteins, and microtubule association [241]