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As significant superoxide source, an uncoupled nitric oxide synthase was identified since a normalization of vascular dysfunction was achieved by administrating the eNOS cofactor tetrahydrobiopterin (BH 4 ) [37] (Fig

Although facial burns will typically prevent application of noninvasive ventilation, the use of high-flow nasal cannula may be considered in selected patients with elevated work of breathing who do not require intubation (with very careful observation)

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