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They are important signaling intercessors, playing roles in tumor growth, TME remodeling, metastasis, angiogenesis, as well as treatment resistance [260, 261]

Traditional treatments (topical steroids, biologics, immunosuppressants) target these pathways directly

Density features of heme highlight that the heme molecule is rigidified during the process of binding and confinement

If you're ordering from outside the US, confirm the current estimate directly with support rather than relying on either figure alone

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Statements Author contributions AL: Writing original draft