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Seek medical attention if nodes remain enlarged beyond one month, feel hard or immovable, or occur with concerning symptoms like significant weight loss

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[DOI] [PubMed] [Google Scholar] 42.Bilic M, Bumber Z, Blagaic AB, Batelja L, Seiwerth S, Sikiric P

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This increase in ECM proteins fibrosis separates the individual bundles of muscle cells and disturbs the impulse propagation that causes the heart to beat regularly.[ref] Animal studies from about a decade ago show a pressure overload in the heart (stressing out the heart) can cause mast cells to proliferate

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