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The peptide disrupted FOXO4-p53 co-localization at PML nuclear bodies, releasing p53 to translocate to the mitochondria and trigger the intrinsic apoptosis pathway (Baar et al., 2017)

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Protocols vary depending on research goals

(PubMed) How TB-500 Works TB-500 is not full-length TB4 its the N-acetylated 1723 fragment (Ac-LKKTETQ) that corresponds to TB4s actin-binding region

Miller EJ, Matukas VJ (1969) Chick cartilage collagen: a new type of alpha 1 chain not present in bone or skin of the species

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