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Similarly, also cellcell adhesion, mediated by cadherins, is widely known to be critical for tissue homeostasis and maintenance of cell polarity

"Nuclear transport, oxidative stress, and neurodegeneration"

J Clin Investig 118:829838

We studied the pathophysiological mechanism of the disease in 2 NEU1-deficient mouse models, a constitutive Neu1 -knockout, Neu1 Ex3 , and a conditional phagocyte-specific knockout, Neu1 Cx3cr1Ex3