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We seek to present a comprehensive clinical application prospect of infliximab in TBI and, thus, discuss potential strategies of infliximab in treating TBI

FIGURE 4 Novel drug modalities for NRF2 activation Up to date, the only NRF2 activators in clinical use are DMF for MS (Rosito et al., 2020), and more recently Omaveloxolone, a semisynthetic terpenoid with potent NRF2-activating effects gained FDA approval in Februrary 2023 for the treatment of Friederichs ataxia ( However, most NRF2 activators are of electrophilic nature and exhibit unpredictable poly-pharmacology

H 2 O 2 , derived from the catalytic reduction of the radical anion superoxide (O 2 - ), can be produced by mitochondria and is found in breast milk

Lancet 374(9699):14491461 Martin GR, Wallace JL (2006) Gastrointestinal inflammation: a central component of mucosal defense and repair

Likewise, TNF is indirectly activated by both drugs, which implies a potential immunomodulatory role for MPH and LDX

Skin color is determined by the quantity of melanosomes and their extent of dispersion in the skin (5)