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Nature 417 , 975978 (2002)

reduced the serum level of lipid peroxidation (LPO) and myeloperoxidase (MPO) activity and improved the GSH and SOD in rat lung sepsis model [64], decreasing lung inflammation and tracheal response with efficacy similar to vitamin C in guinea pigs subjected to cigarette smoke (COPD guinea pig model) [65], reducing the count of eosinophils in the peripheral blood and inflammatory cells in the lung tissue of the mice model of allergic asthma, with efficacy similar to the effects of dexamethasone [66], normalization of serum malondialdehyde (MDA), IL-8 levels, WBC total changes, eosinophils, neutrophils and lymphocyte ratios in a guinea pig model of COPD [67], improving WBC count, serum levels of IL-6 and SOD activity in heart and lung injury in mice induced by diesel exhaust particles (DEP) [68], mitigating changes in lung and serum biomarkers correlated with inflammatory reactions, with less lipid peroxidation (LPO) and recovery of antioxidants

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Goodman WG, Quarles LD (2008) Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics

However, substitution can help if you experience withdrawal between doses on shorter-acting medications [5][6]