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Previous studies have shown that PPAR expression is significantly upregulated in WAT of obese individuals, thereby facilitating adipocyte differentiation and de novo lipogenesis [10, 11]

doi: 10.1038/s41591-018-0014-x 261 YangY

or more as an adult)

Near-infrared II nanoadjuvant-mediated chemodynamic, photodynamic, and photothermal therapy combines immunogenic cell death with PD-L1 blockade to enhance antitumor immunity

This amplifies tissue injury and highlights ferroptosis as a therapeutic target for IRI-related pathologies ( In cancer cells, chronic oxidative stress often creates selective vulnerability due to impaired GSH metabolism

doi: 10.7326/0003-4819-75-5-822_4 [DOI] [Google Scholar] Felsenfeld O, and Wolf RH (1973)