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Integrated metabolomic profiling of IBD patients and murine colitis models revealed significant depletion of the microbiota-derived metabolite indole-3-propionic acid (IPA)

8 Consistent with prior studies showing that AHCY inhibition disrupts the methionine cycle, lowers SAM levels, and reduces tumor burden in Apc-deficient intestinal tumor models 9 an effect corroborated by AHCY-knockout mice generated by Liao et al

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Soil versus foliar iodine fertilization as a biofortification strategy for field-grown vegetables

These MPs can provide unique advantages to drug delivery, such as better safety and improved cellular affinity, enhanced physiochemical features of drugs, and prevention of inappropriate distribution to normal tissues, reducing organ damage and cytotoxicity and resulting in better uptake by tumor cells to increase drug aggregation (393, 394)

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