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10.1038/s41598-021-83545-x 63 XueJ.LiuY.ZhangS.DingL.ShenB.ShaoY.et al (2021)

doi:10.1016/j.jpsychires.2018.12.014 Hidese S, Ota M, Wakabayashi C, et al

The pharmacodynamic concepts of maximum response and sensitivity determine the magnitude of the effect at a particular concentration (see E max and C 50 , Chapter 2

The same dilution procedure was performed using water for injection as a control group

Positively or negatively charged drugs interact differently with the endothelial glycocalyx and may also show different binding characteristics or transporter affinities if the glycocalyx is altered in PD [47, 49, 308]

We further evaluated the selectivity of most active compounds ( 9r , 9m , 9d and 9h ) against HDAC1 as a representative of class I HDAC enzymes, HDAC4, a member of class IIa, HDAC6 and HDAC10 from class IIb and HDAC11, the only member of class IV