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As it is generally assumed that ghrelin is not reaching the central nervous system, these results suggest that a GhrR and D2R signaling interaction, potentially heterodimerization, is necessary for DA-induced defecation (110)

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A recent drug screening also identified a class I HDAC inhibitor, Vorinostat, as an inducer of ferroptosis in small cell lung cancer (SCLC) and isocitrate dehydrogenase ( IDH1/2 )-mutant brain tumors, suggesting an unique vulnerability that is regulated by histone or non-histone acetylation (84)

(2020) discovered that berberine can augment plasma ApoM and APOM-binding S1P levels during sepsis by inhibiting gluconeogenesis, insulin resistance, and secretion of pro-inflammatory molecules