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European Society of Cardiology 2023 guidelines have given class I C recommendation for IV loop diuretics for relief of signs and symptoms of hypervolemia and class IIa B recommendation for the addition of thiazide-like diuretics in case of resistant edema even after an increase of loop diuretic dose

R., Ghossein, R

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BBB penetration remains a primary bottleneck: natural compounds (curcumin, phillyrin A) and some synthetic agents (DFO) exhibit poor brain bioavailability, necessitating delivery system modification (e.g., nanoparticle conjugates) or structural optimization (e.g., vitamin K analogs)

[DOI] [Google Scholar] 89.Summers A.O., Sugarman L.I

Evaluation of silent information regulator T (SIRT) 1 and forkhead box O (FOXO) transcription factor 1 and 3a genes in glaucoma