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The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

Variation in active compound content between batches, influenced by plant genetics, harvest season, geographic origin, drying conditions, and extraction methods, reduces experimental reproducibility and weakens confidence in preclinical findings

In contrast, endogenous antioxidant systems are a complex and compartmentalized network that involve controlled and localized production of specific ROS [54]

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86 Immunosenescence and aging-related dysregulation of lymphoid lineage cells Lymphoid cells are composed of innate (such as NK cells) and adaptive immune cells (such as T cells and B cells)

Early microglial activation, NF-B signaling, and neuroinflammation in the ONH were also reported in a cat genetic glaucoma model (Oikawa et al., 2020)