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Phytochem Rev 16(6):12271252

Hasan R, Rink L, Haase H

NADPH Oxidase AtrbohD and AtrbohF Genes Function in ROS-Dependent ABA Signaling in Arabidopsis

Of these, five proteins were cytokines (Interleukin (IL)-1, IL-5, IL-15, IL-16 IL-17B) the secretion of which were significantly increased following metformin treatment, when compared to vehicle control ( Figures 7AE )

Molenaar et al, Mol

Also, field experiments offer a more realistic setting with uncontrolled variables, but can be difficult to replicate and may produce contradictory results due to environmental variability