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Studies of effects of trans fatty acids in the diet on lipid metabolism in essential fatty acid deficient rats

Based on these findings, together with our experimental observation of enhanced STINGTBK1IFN- activation in the MnUA group, we speculate that the superior immunostimulatory effect of MnUA may result from MSU-mediated NF-B priming, which augments STING pathway activation in the presence of Mn.Collectively, these results suggest that MnUA may promote innate immune activation through the coordinated engagement of NF-B and STING signaling pathways

K.LiY.WangL.ZhangW.et al

Zhang, X., Hu, X., Hou, A

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This biomechanical alteration activates the YAP/TAZdependent mechanotransduction pathway, further inducing the upregulation of downstream effector proteins, including GLS1, LDHA, and SLC1A3