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Senescent cells are often characterized by alterations in morphology, metabolism, chromatin remodeling and exhibit a complex pro-inflammatory secretome (SASP)

The effect of aspirin on Circulating tumor cells in metastatic colorectal and breast cancer patients: a phase II trial study

Its principal physiological role is as one of the most important intracellular antioxidants neutralizing oxidative stress, supporting detoxification pathways, and maintaining the redox balance of the cell

Signoretti, C

These models are essential for investigating mitochondrial biology, assessing the functional impact of genetic mutations, facilitating exploration of multi-factorial pathologies resulting from underlying mitochondrial dysfunction, and evaluating potential therapeutic strategies

HIFs are mainly regulated by changes in protein stability and transcriptional activity in an O 2 -dependent manner