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An additional constraint could arise from the fact that while ferrostatin-1 has also previously shown efficacy in inhibiting ferroptosis in other human organoid models, such as bronchial [56] and gut crypt organoids [57], its utility is hindered by its solubility issues

Markers of microbial dysbiosis, such as shifts in the Firmicutes/Bacteroidetes ratio, reduction in butyrate-producing species, and increased LPS levels, may serve as early indicators of circadian-gut axis dysfunction 260