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doi: 10.3390/ani12172299 113 KltzD

FIGURE 6 Statements Author contributions JZ, QZ, and ZC conceived and designed the manuscript

An ongoing phase Ib trial (NCT04167540) is designed to evaluate the safety and potential clinical effect of MRI-guided intraputaminal delivery of AAV2-GDNF in two cohorts of patients with either early-stage or advanced PD, thus contributing with important knowledge on the therapeutic effect early in PD course