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At minimum, check metabolic panels, liver function, lipid profiles, and fasting glucose before starting and every 8-12 weeks during combination therapy

51 , 575586.e574 (2019)

Elongate the duration of channel opening (whereas benzodiazepins increase the frequency of channel opening)

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Optimal results can take up to 16 weeks for some people

Gradient elution at a 0.45 mL/min was as follows: mobile phase MPB1 was held at 20% for the first 1 min, and linearly increased to 25% in 30 s, and then to 50% and 60% in 16.5 min and 3.0 min, respectively