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[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Brelstaff JH, et al

modulation of transforming growth factor beta (TGF-)

Although the current therapeutic practices have significant variability in routes and dosage regimens, we concluded that management of IGS predominantly centers on lifelong Vitamin B12 supplementation, which is sufficient for preventing hematological and neurological abnormalities associated with this disorder

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Taken together, these data provide further understanding into the regulation of CBS and in particular into the genetic relationship between DYRK1A and CBS through the Akt/GSK3 and NF-B pathways, which should help develop more effective therapies to reduce cognitive deficits in people with DS

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