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One very important thing we are noticing, and reporting: CIRS patients all have difficulty concentrating and often come to me on Adderall

The plateau-breaking potential is one of the primary reasons clinicians combine these compounds

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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured