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Rating: 4.4815000000000005 (16 reviews)

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SKU: 8814555943 · From reganhouse.co.nz

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Description

Cons: Can be sedating in high doses

M.LiuN.StephanopoulosG.AlperH

doi:10.1038/s41583-019-0132-6 CrossRef Cummings JL, Tong G, Ballard C

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These lignans, including schisandrin B (Sch B), schisandrin A (Sch A), and deoxyschisandrin (DS), have been demonstrated to ameliorate MASLD through multiple mechanisms: activation of PPAR- to promote fatty acid (FA) oxidation, inhibition of the LXR-/sterol regulatory element-binding protein 1c (SREBP-1c)/FAS pathway to reduce de novo lipogenesis, activation of the AMPK/mTOR autophagy pathway to decrease hepatic lipid accumulation, and suppression of pro-inflammatory cytokines to attenuate hepatic inflammation