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31 confirmed stronger expression of ACSL1, but not ACSL4, in U-CLL cells (Fig

disproportionate to activity level Pallor particularly of conjunctiva, nail beds, and palmar creases Tachycardia and palpitations compensatory response to reduced oxygen-carrying capacity Dyspnea on exertion worsening with progressive anemia Dizziness/lightheadedness/syncope especially with acute blood loss and volume depletion Hypotension in acute hemorrhagic cases

However, these in vitro studies often use relatively high Mn concentrations (up to 1 mM), exceeding physiological brain Mn levels, but acute culture systems generally require higher doses to reveal mechanistic effects in the absence of the physiological environment

The mechanism of plant resistance to heavy metal

Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, et al

PMID: 33931130