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The observed increase in hippocampal BDNF levels in Mg-citrate-treated groups, despite unchanged Mg concentrations in the hippocampus, may arise from systemic or indirect neural mechanisms rather than direct local Mg accumulation

Cellular studies have shown that exogenous NAD + can impact mitochondrial activity, such as boosting Krebs cycle and the ETC, but also impair genomic DNA replication and induce DNA replication stress due to impairment of pyrimidine biosynthesis 118

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For instance, SIRT7 has been identified as a key player in the pathogenesis of immune-mediated intestinal inflammation, specifically in inflammatory bowel disease (IBD)

Phytother Res: PTR 22(10):13611366 Moses T, Papadopoulou KK, Osbourn A (2014) Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

Synergistic Effects in Regenerative Blends : When combined with peptides such as BPC-157 or TB-500 , GHK-Cu enhances tissue repair through complementary mechanismsangiogenesis, fibroblast stimulation, and collagen synthesis